7MJS

Single-Particle Cryo-EM Structure of Major Facilitator Superfamily Domain containing 2A in complex with LPC-18:3

Summary for 7MJS

Entry DOI	10.2210/pdb7mjs/pdb
EMDB information	23883
Descriptor	2AG3 Fab heavy chain, 2AG3 Fab light chain, Major Facilitator Superfamily Domain containing 2A, ... (5 entities in total)
Functional Keywords	mfs transporters, lysolipids, blood-brain barrier, omega-3 fatty acids, lipid transport-immune system complex, lipid transport/immune system
Biological source	Synthetic construct More
Total number of polymer chains	3
Total formula weight	111051.95
Authors	Cater, R.J.,Chua, G.L.,Erramilli, S.K.,Keener, J.E.,Choy, B.C.,Tokarz, P.,Chin, C.F.,Quek, D.Q.Y.,Kloss, B.,Pepe, J.G.,Parisi, G.,Wong, B.H.,Clarke, O.B.,Marty, M.T.,Kossiakoff, A.A.,Khelashvili, G.,Silver, D.L.,Mancia, F. (deposition date: 2021-04-20, release date: 2021-06-16, Last modification date: 2021-07-28)
Primary citation	Cater, R.J.,Chua, G.L.,Erramilli, S.K.,Keener, J.E.,Choy, B.C.,Tokarz, P.,Chin, C.F.,Quek, D.Q.Y.,Kloss, B.,Pepe, J.G.,Parisi, G.,Wong, B.H.,Clarke, O.B.,Marty, M.T.,Kossiakoff, A.A.,Khelashvili, G.,Silver, D.L.,Mancia, F. Structural basis of omega-3 fatty acid transport across the blood-brain barrier. Nature, 595:315-319, 2021 Cited by PubMed: 34135507 DOI: 10.1038/s41586-021-03650-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.03 Å)

Structure validation