7MJS

Single-Particle Cryo-EM Structure of Major Facilitator Superfamily Domain containing 2A in complex with LPC-18:3

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0005783	cellular_component	endoplasmic reticulum
X	0005789	cellular_component	endoplasmic reticulum membrane
X	0005886	cellular_component	plasma membrane
X	0006869	biological_process	lipid transport
X	0008643	biological_process	carbohydrate transport
X	0015245	molecular_function	fatty acid transmembrane transporter activity
X	0015293	molecular_function	symporter activity
X	0015908	biological_process	fatty acid transport
X	0016020	cellular_component	membrane
X	0051978	molecular_function	lysophospholipid:sodium symporter activity
X	0055085	biological_process	transmembrane transport
X	0140329	biological_process	lysophospholipid translocation
X	1990379	biological_process	lipid transport across blood-brain barrier

Functional Information from PROSITE/UniProt

site_id	PS00092
Number of Residues	7
Details	N6_MTASE N-6 Adenine-specific DNA methylases signature. CIENPPF

Chain	Residue	Details
X	CYS207-PHE213

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR213-HIS219
L	TYR195-HIS201

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	130
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:34135507, ECO:0007744|PDB:7MJS

Chain	Residue	Details
X	MET1-SER37
X	SER100-ARG109
X	ALA162-SER176
X	VAL264-ILE295
X	THR352-GLY355
X	LEU491-VAL528

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site_id	SWS_FT_FI2
Number of Residues	268
Details	TRANSMEM: Helical => ECO:0000269|PubMed:34135507, ECO:0007744|PDB:7MJS

Chain	Residue	Details
X	VAL38-LEU66
X	VAL382-SER404
X	PHE428-LEU450
X	ILE468-LYS490
X	PRO74-ILE99
X	LEU110-TRP129
X	VAL139-SER161
X	ALA177-ILE199
X	TYR242-GLY263
X	LYS296-CYS319
X	PHE329-LEU351
X	LYS356-VAL376

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site_id	SWS_FT_FI3
Number of Residues	83
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:34135507, ECO:0007744|PDB:7MJS

Chain	Residue	Details
X	LEU67-ASP73
X	PHE130-GLN138
X	VAL200-ALA241
X	THR320-GLU328
X	LEU377-LEU381
X	ASP451-ASN467

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site_id	SWS_FT_FI4
Number of Residues	22
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
X	MET405-PHE427

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:34135507, ECO:0007744|PDB:7MJS

Chain	Residue	Details
X	ASN218
X	ASN227

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