7MEU
A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders
Summary for 7MEU
Entry DOI | 10.2210/pdb7meu/pdb |
Descriptor | Eukaryotic translation initiation factor 4E, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, (2E)-2-{2-[4-([1,1'-biphenyl]-4-yl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, eif4e, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 46373.82 |
Authors | Papadopoulos, E. (deposition date: 2021-04-07, release date: 2021-04-28, Last modification date: 2023-10-18) |
Primary citation | Fischer, P.D.,Papadopoulos, E.,Dempersmier, J.M.,Wang, Z.F.,Nowak, R.P.,Donovan, K.A.,Kalabathula, J.,Gorgulla, C.,Junghanns, P.P.M.,Kabha, E.,Dimitrakakis, N.,Petrov, O.I.,Mitsiades, C.,Ducho, C.,Gelev, V.,Fischer, E.S.,Wagner, G.,Arthanari, H. A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders. Eur.J.Med.Chem., 219:113435-113435, 2021 Cited by PubMed: 33892272DOI: 10.1016/j.ejmech.2021.113435 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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