7MEU

A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders

7MEU の概要

• エントリーDOI: 10.2210/pdb7meu/pdb
• 分子名称: Eukaryotic translation initiation factor 4E, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, (2E)-2-{2-[4-([1,1'-biphenyl]-4-yl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, eif4e, protein binding
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46373.82

構造登録者

Papadopoulos, E. (登録日: 2021-04-07, 公開日: 2021-04-28, 最終更新日: 2023-10-18)

• 主引用文献: Fischer, P.D.,Papadopoulos, E.,Dempersmier, J.M.,Wang, Z.F.,Nowak, R.P.,Donovan, K.A.,Kalabathula, J.,Gorgulla, C.,Junghanns, P.P.M.,Kabha, E.,Dimitrakakis, N.,Petrov, O.I.,Mitsiades, C.,Ducho, C.,Gelev, V.,Fischer, E.S.,Wagner, G.,Arthanari, H.; A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders.; Eur.J.Med.Chem., 219:113435-113435, 2021; PubMed: 33892272; DOI: 10.1016/j.ejmech.2021.113435

実験手法

X-RAY DIFFRACTION (1.91 Å)