7MES
Structure of ALDH4A1 complexed with trans-4-Hydroxy-D-proline
Summary for 7MES
Entry DOI | 10.2210/pdb7mes/pdb |
Descriptor | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (4S)-4-hydroxy-D-proline, ... (8 entities in total) |
Functional Keywords | aldehyde dehydrogenase, rossmann fold, nucleotide binding, acting on aldehyde or oxo group of donors, nad or nadp as acceptor, mitochondria, oxidoreductase |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 2 |
Total formula weight | 126899.11 |
Authors | Bogner, A.N.,Stiers, K.M.,Tanner, J.J. (deposition date: 2021-04-07, release date: 2021-06-09, Last modification date: 2023-10-18) |
Primary citation | Bogner, A.N.,Stiers, K.M.,McKay, C.M.,Becker, D.F.,Tanner, J.J. Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzyme ALDH4A1 by trans-4-hydroxy-L-proline. Protein Sci., 30:1714-1722, 2021 Cited by PubMed: 34048122DOI: 10.1002/pro.4131 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.37 Å) |
Structure validation
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