7M2E
Crystal structure of BPTF bromodomain in complex with CB02-092
Summary for 7M2E
Entry DOI | 10.2210/pdb7m2e/pdb |
Descriptor | Nucleosome-remodeling factor subunit BPTF, 4-chloro-5-{4-[2-(dimethylamino)ethyl]anilino}-2-methylpyridazin-3(2H)-one (3 entities in total) |
Functional Keywords | bptf, bromodomain, bromodomain inhibitor, gene regulation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 14762.21 |
Authors | Nithianantham, S.,Fischer, M. (deposition date: 2021-03-16, release date: 2022-02-16, Last modification date: 2023-10-18) |
Primary citation | Zahid, H.,Buchholz, C.R.,Singh, M.,Ciccone, M.F.,Chan, A.,Nithianantham, S.,Shi, K.,Aihara, H.,Fischer, M.,Schonbrunn, E.,dos Santos, C.O.,Landry, J.W.,Pomerantz, W.C.K. New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition J.Med.Chem., 64:13902-13917, 2021 Cited by DOI: 10.1021/acs.jmedchem.1c01294PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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