7M18

HeLa-tubulin in complex with cryptophycin 1

Summary for 7M18

• Entry DOI: 10.2210/pdb7m18/pdb
• Related: 7LXB
• EMDB information: 23569 23615
• Descriptor: Tubulin beta-3 chain, Tubulin alpha-1B chain, Cryptophycin 1, ... (5 entities in total)
• Functional Keywords: anti-tumor, microtubule, tubulin-rings, polymerization-inhibitor, cell cycle
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 16
• Total formula weight: 818460.19

Authors

Eren, E. (deposition date: 2021-03-12, release date: 2021-09-08, Last modification date: 2024-05-29)

• Primary citation: Eren, E.,Watts, N.R.,Sackett, D.L.,Wingfield, P.T.; Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action.; J.Biol.Chem., 297:101138-101138, 2021; PubMed: 34461087; DOI: 10.1016/j.jbc.2021.101138

Experimental method

ELECTRON MICROSCOPY (3.38 Å)