7LU5
SAMHD1(113-626) H206R D207N R366H
Summary for 7LU5
Entry DOI | 10.2210/pdb7lu5/pdb |
Related | 7LTT |
Descriptor | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE (2 entities in total) |
Functional Keywords | dntpase, tetramer, mutant, cancer, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 16 |
Total formula weight | 1006432.80 |
Authors | Temple, J.T.,Bowen, N.E. (deposition date: 2021-02-20, release date: 2021-11-24, Last modification date: 2023-10-18) |
Primary citation | Bowen, N.E.,Temple, J.,Shepard, C.,Oo, A.,Arizaga, F.,Kapoor-Vazirani, P.,Persaud, M.,Yu, C.H.,Kim, D.H.,Schinazi, R.F.,Ivanov, D.N.,Diaz-Griffero, F.,Yu, D.S.,Xiong, Y.,Kim, B. Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins. J.Biol.Chem., 297:101170-101170, 2021 Cited by PubMed: 34492268DOI: 10.1016/j.jbc.2021.101170 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.57 Å) |
Structure validation
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