7LU5

SAMHD1(113-626) H206R D207N R366H

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:22056990

Chain	Residue	Details
A	HIS233
J	HIS233
K	HIS233
L	HIS233
M	HIS233
N	HIS233
O	HIS233
P	HIS233
B	HIS233
C	HIS233
D	HIS233
E	HIS233
F	HIS233
G	HIS233
H	HIS233
I	HIS233

---

site_id	SWS_FT_FI2
Number of Residues	96
Details	BINDING: in other chain => ECO:0000269|PubMed:24141705, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:25267621, ECO:0000269|PubMed:25288794, ECO:0000269|PubMed:25760601, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200

Chain	Residue	Details
A	LYS116
B	ARG352
B	ASN358
B	LYS523
C	LYS116
C	ASP137
C	ARG333
C	ARG352
C	ASN358
C	LYS523
D	LYS116
A	ASP137
D	ASP137
D	ARG333
D	ARG352
D	ASN358
D	LYS523
E	LYS116
E	ASP137
E	ARG333
E	ARG352
E	ASN358
A	ARG333
E	LYS523
F	LYS116
F	ASP137
F	ARG333
F	ARG352
F	ASN358
F	LYS523
G	LYS116
G	ASP137
G	ARG333
A	ARG352
G	ARG352
G	ASN358
G	LYS523
H	LYS116
H	ASP137
H	ARG333
H	ARG352
H	ASN358
H	LYS523
I	LYS116
A	ASN358
I	ASP137
I	ARG333
I	ARG352
I	ASN358
I	LYS523
J	LYS116
J	ASP137
J	ARG333
J	ARG352
J	ASN358
A	LYS523
J	LYS523
K	LYS116
K	ASP137
K	ARG333
K	ARG352
K	ASN358
K	LYS523
L	LYS116
L	ASP137
L	ARG333
B	LYS116
L	ARG352
L	ASN358
L	LYS523
M	LYS116
M	ASP137
M	ARG333
M	ARG352
M	ASN358
M	LYS523
N	LYS116
B	ASP137
N	ASP137
N	ARG333
N	ARG352
N	ASN358
N	LYS523
O	LYS116
O	ASP137
O	ARG333
O	ARG352
O	ASN358
B	ARG333
O	LYS523
P	LYS116
P	ASP137
P	ARG333
P	ARG352
P	ASN358
P	LYS523

---

site_id	SWS_FT_FI3
Number of Residues	80
Details	BINDING: BINDING => ECO:0000269|PubMed:24141705, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:25267621, ECO:0000269|PubMed:25288794, ECO:0000269|PubMed:25760601, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200

Chain	Residue	Details
A	ASN119
B	LYS455
C	ASN119
C	HIS376
C	LYS377
C	ARG451
C	LYS455
D	ASN119
D	HIS376
D	LYS377
D	ARG451
A	HIS376
D	LYS455
E	ASN119
E	HIS376
E	LYS377
E	ARG451
E	LYS455
F	ASN119
F	HIS376
F	LYS377
F	ARG451
A	LYS377
F	LYS455
G	ASN119
G	HIS376
G	LYS377
G	ARG451
G	LYS455
H	ASN119
H	HIS376
H	LYS377
H	ARG451
A	ARG451
H	LYS455
I	ASN119
I	HIS376
I	LYS377
I	ARG451
I	LYS455
J	ASN119
J	HIS376
J	LYS377
J	ARG451
A	LYS455
J	LYS455
K	ASN119
K	HIS376
K	LYS377
K	ARG451
K	LYS455
L	ASN119
L	HIS376
L	LYS377
L	ARG451
B	ASN119
L	LYS455
M	ASN119
M	HIS376
M	LYS377
M	ARG451
M	LYS455
N	ASN119
N	HIS376
N	LYS377
N	ARG451
B	HIS376
N	LYS455
O	ASN119
O	HIS376
O	LYS377
O	ARG451
O	LYS455
P	ASN119
P	HIS376
P	LYS377
P	ARG451
B	LYS377
P	LYS455
B	ARG451

---

site_id	SWS_FT_FI4
Number of Residues	128
Details	BINDING: BINDING => ECO:0000269|PubMed:24141705

Chain	Residue	Details
A	GLN149
B	ARG164
M	ASP309
M	TYR315
M	ASP319
M	HIS366
M	HIS370
N	GLN149
N	ARG164
N	HIS210
N	ASP309
N	TYR315
B	HIS210
N	ASP319
N	HIS366
N	HIS370
O	GLN149
O	ARG164
O	HIS210
O	ASP309
O	TYR315
O	ASP319
O	HIS366
B	ASP309
O	HIS370
P	GLN149
P	ARG164
P	HIS210
P	ASP309
P	TYR315
P	ASP319
P	HIS366
P	HIS370
B	TYR315
B	ASP319
B	HIS366
B	HIS370
C	GLN149
C	ARG164
C	HIS210
A	ARG164
C	ASP309
C	TYR315
C	ASP319
C	HIS366
C	HIS370
D	GLN149
D	ARG164
D	HIS210
D	ASP309
D	TYR315
A	HIS210
D	ASP319
D	HIS366
D	HIS370
E	GLN149
E	ARG164
E	HIS210
E	ASP309
E	TYR315
E	ASP319
E	HIS366
A	ASP309
E	HIS370
F	GLN149
F	ARG164
F	HIS210
F	ASP309
F	TYR315
F	ASP319
F	HIS366
F	HIS370
G	GLN149
A	TYR315
G	ARG164
G	HIS210
G	ASP309
G	TYR315
G	ASP319
G	HIS366
G	HIS370
H	GLN149
H	ARG164
H	HIS210
A	ASP319
H	ASP309
H	TYR315
H	ASP319
H	HIS366
H	HIS370
I	GLN149
I	ARG164
I	HIS210
I	ASP309
I	TYR315
A	HIS366
I	ASP319
I	HIS366
I	HIS370
J	GLN149
J	ARG164
J	HIS210
J	ASP309
J	TYR315
J	ASP319
J	HIS366
A	HIS370
J	HIS370
K	GLN149
K	ARG164
K	HIS210
K	ASP309
K	TYR315
K	ASP319
K	HIS366
K	HIS370
L	GLN149
B	GLN149
L	ARG164
L	HIS210
L	ASP309
L	TYR315
L	ASP319
L	HIS366
L	HIS370
M	GLN149
M	ARG164
M	HIS210

---

site_id	SWS_FT_FI5
Number of Residues	64
Details	BINDING: BINDING => ECO:0000269|PubMed:24141705, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:25288794, ECO:0000269|PubMed:25760601, ECO:0000269|PubMed:26431200

Chain	Residue	Details
A	HIS167
C	ARG206
C	ASN207
C	ASP311
D	HIS167
D	ARG206
D	ASN207
D	ASP311
E	HIS167
E	ARG206
E	ASN207
A	ARG206
E	ASP311
F	HIS167
F	ARG206
F	ASN207
F	ASP311
G	HIS167
G	ARG206
G	ASN207
G	ASP311
H	HIS167
A	ASN207
H	ARG206
H	ASN207
H	ASP311
I	HIS167
I	ARG206
I	ASN207
I	ASP311
J	HIS167
J	ARG206
J	ASN207
A	ASP311
J	ASP311
K	HIS167
K	ARG206
K	ASN207
K	ASP311
L	HIS167
L	ARG206
L	ASN207
L	ASP311
M	HIS167
B	HIS167
M	ARG206
M	ASN207
M	ASP311
N	HIS167
N	ARG206
N	ASN207
N	ASP311
O	HIS167
O	ARG206
O	ASN207
B	ARG206
O	ASP311
P	HIS167
P	ARG206
P	ASN207
P	ASP311
B	ASN207
B	ASP311
C	HIS167

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	MOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200, ECO:0000269|PubMed:29610582, ECO:0000269|PubMed:29670289, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	THR592
J	THR592
K	THR592
L	THR592
M	THR592
N	THR592
O	THR592
P	THR592
B	THR592
C	THR592
D	THR592
E	THR592
F	THR592
G	THR592
H	THR592
I	THR592

---

site_id	SWS_FT_FI7
Number of Residues	80
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS467
B	LYS622
C	LYS467
C	LYS469
C	LYS492
C	LYS622
D	LYS467
D	LYS469
D	LYS492
D	LYS622
E	LYS467
E	LYS469
E	LYS492
E	LYS622
F	LYS467
F	LYS469
F	LYS492
A	LYS469
F	LYS622
G	LYS467
G	LYS469
G	LYS492
G	LYS622
H	LYS467
H	LYS469
H	LYS492
A	LYS492
H	LYS622
I	LYS467
I	LYS469
I	LYS492
I	LYS622
J	LYS467
J	LYS469
J	LYS492
A	LYS622
J	LYS622
K	LYS467
K	LYS469
K	LYS492
K	LYS622
L	LYS467
L	LYS469
L	LYS492
B	LYS467
L	LYS622
M	LYS467
M	LYS469
M	LYS492
M	LYS622
N	LYS467
N	LYS469
N	LYS492
N	LYS622
O	LYS467
O	LYS469
O	LYS492
O	LYS622
P	LYS467
P	LYS469
P	LYS492
B	LYS469
P	LYS622
B	LYS492

---