7LU5

SAMHD1(113-626) H206R D207N R366H

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	polymer	535	61887.7	16	UniProt (Q9Y3Z3) Pfam (PF01966)	Homo sapiens (Human)	dNTPase,Dendritic cell-derived IFNG-induced protein,DCIP,Monocyte protein 5,MOP-5,SAM domain and HD domain-containing protein 1,hSAMHD1
2	AA, BA, CA, DA, EA... (E, F, G, H, I...)	2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	32	Chemie (DGT)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P: 113 - 626 (UniProt: Q9Y3Z3)

PDB	External Database	Details
Met 92	-	initiating methionine
Gly 93	-	expression tag
Ser 94	-	expression tag
Ser 95	-	expression tag
His 96	-	expression tag
His 97	-	expression tag
His 98	-	expression tag
His 99	-	expression tag
His 100	-	expression tag
His 101	-	expression tag
Ser 102	-	expression tag
Ser 103	-	expression tag
Gly 104	-	expression tag
Leu 105	-	expression tag
Val 106	-	expression tag
Pro 107	-	expression tag
Arg 108	-	expression tag
Gly 109	-	expression tag
Ser 110	-	expression tag
His 111	-	expression tag
Met 112	-	expression tag
Arg 206	His 206	engineered mutation
Asn 207	Asp 207	engineered mutation
His 366	Arg 366	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	990203.0
Non-Polymers*	Number of molecules	32
	Total formula weight	16229.8
All*	Total formula weight	1006432.8

*Water molecules are not included.