7LQ1

HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 28

Summary for 7LQ1

• Entry DOI: 10.2210/pdb7lq1/pdb
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, N-(5-(6-(2-((2S,6R)-2,6-dimethylmorpholino)pyridin-4-yl)-1-oxoisoindolin-4-yl)-2-methoxypyridin-3-yl)methanesulfonamide, ... (5 entities in total)
• Functional Keywords: pi3kdelta kinase, transferase, transferase-transferase inhibitor complex
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 141071.64

Authors

Lesburg, C.A.,Augustin, M. (deposition date: 2021-02-12, release date: 2022-02-16, Last modification date: 2024-04-03)

• Primary citation: Fradera, X.,Deng, Q.,Achab, A.,Garcia, Y.,Kattar, S.D.,McGowan, M.A.,Methot, J.L.,Wilson, K.,Zhou, H.,Shaffer, L.,Goldenblatt, P.,Tong, V.,Augustin, M.A.,Altman, M.D.,Lesburg, C.A.,Shah, S.,Katz, J.D.; Discovery of a new series of PI3K-delta inhibitors from Virtual Screening.; Bioorg.Med.Chem.Lett., 42:128046-128046, 2021; PubMed: 33865969; DOI: 10.1016/j.bmcl.2021.128046

Experimental method

X-RAY DIFFRACTION (2.96 Å)