7LQ1
HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 28
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | polymer | 1044 | 119633.0 | 1 | UniProt (O00329) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (Human) | PI3-kinase subunit delta,PI3K-delta,PI3Kdelta,PtdIns-3-kinase subunit delta,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta,PtdIns-3-kinase subunit p110-delta,p110delta |
| 2 | B | Phosphatidylinositol 3-kinase regulatory subunit alpha | polymer | 169 | 20879.6 | 1 | UniProt (P27986) Pfam (PF16454) In PDB | Homo sapiens (Human) | PtdIns-3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PtdIns-3-kinase regulatory subunit p85-alpha |
| 3 | A | N-(5-(6-(2-((2S,6R)-2,6-dimethylmorpholino)pyridin-4-yl)-1-oxoisoindolin-4-yl)-2-methoxypyridin-3-yl)methanesulfonamide | non-polymer | 523.6 | 1 | Chemie (YA7) | |||
| 4 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
B: 431 - 599 (UniProt: P27986)
| PDB | External Database | Details |
|---|---|---|
| Asp 469 | Glu 169 | conflict |
| Thr 519 | Lys 219 | conflict |
| Glu 529 | Asp 229 | conflict |
| Val 539 | Ile 239 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 140512.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 559.1 | |
| All* | Total formula weight | 141071.6 |
