7LO9
RNA dodecamer containing a GNA A residue
Summary for 7LO9
Entry DOI | 10.2210/pdb7lo9/pdb |
Descriptor | Chains: A,B,C,D (2 entities in total) |
Functional Keywords | rna crystal structure, glycol nucleic acid, rna |
Biological source | synthetic construct |
Total number of polymer chains | 4 |
Total formula weight | 15488.88 |
Authors | Harp, J.M.,Wawrzak, Z.,Egli, M. (deposition date: 2021-02-09, release date: 2021-12-22, Last modification date: 2024-05-22) |
Primary citation | Schlegel, M.K.,Matsuda, S.,Brown, C.R.,Harp, J.M.,Barry, J.D.,Berman, D.,Castoreno, A.,Schofield, S.,Szeto, J.,Manoharan, M.,Charisse, K.,Egli, M.,Maier, M.A. Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs. Nucleic Acids Res., 49:10851-10867, 2021 Cited by PubMed: 34648028DOI: 10.1093/nar/gkab916 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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