7LM9

Crystal structure of SARS-CoV spike protein receptor-binding domain in complex with a cross-neutralizing antibody CV38-142 Fab isolated from COVID-19 patient

Summary for 7LM9

Entry DOI	10.2210/pdb7lm9/pdb
Descriptor	Spike glycoprotein, CV38-142 Fab heavy chain, CV38-142 Fab light chain, ... (6 entities in total)
Functional Keywords	sars-cov, antibody, spike, coronavirus, sars, immune system, viral protein-immune system complex, cross-neutralization, viral protein, viral protein/immune system
Biological source	SARS coronavirus MA15 More
Total number of polymer chains	3
Total formula weight	75148.97
Authors	Liu, H.,Yuan, M.,Zhu, X.,Wilson, I.A. (deposition date: 2021-02-05, release date: 2021-03-31, Last modification date: 2023-10-18)
Primary citation	Liu, H.,Yuan, M.,Huang, D.,Bangaru, S.,Zhao, F.,Lee, C.D.,Peng, L.,Barman, S.,Zhu, X.,Nemazee, D.,Burton, D.R.,van Gils, M.J.,Sanders, R.W.,Kornau, H.C.,Reincke, S.M.,Pruss, H.,Kreye, J.,Wu, N.C.,Ward, A.B.,Wilson, I.A. A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection. Cell Host Microbe, 29:806-818.e6, 2021 Cited by PubMed: 33894127 DOI: 10.1016/j.chom.2021.04.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation