7LM9
Crystal structure of SARS-CoV spike protein receptor-binding domain in complex with a cross-neutralizing antibody CV38-142 Fab isolated from COVID-19 patient
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Spike glycoprotein | polymer | 230 | 25982.3 | 1 | UniProt (D2E265) Pfam (PF09408) | SARS coronavirus MA15 | S glycoprotein,E2,Peplomer protein |
| 2 | B (H) | CV38-142 Fab heavy chain | polymer | 226 | 24068.0 | 1 | Homo sapiens (Human) | ||
| 3 | C (L) | CV38-142 Fab light chain | polymer | 217 | 23745.3 | 1 | Homo sapiens (Human) | ||
| 4 | D (B) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
| 5 | E, F, G, H, I... (A, H, L) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 6 | O, P, Q (A, H, L) | water | water | 18.0 | 593 | Chemie (HOH) |
Sequence modifications
A: 306 - 527 (UniProt: D2E265)
| PDB | External Database | Details |
|---|---|---|
| Ser 528 | - | expression tag |
| Gly 529 | - | expression tag |
| His 530 | - | expression tag |
| His 531 | - | expression tag |
| His 532 | - | expression tag |
| His 533 | - | expression tag |
| His 534 | - | expression tag |
| His 535 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 73795.6 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 732.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 620.7 | |
| All* | Total formula weight | 75149.0 |
