7LM2

HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 3C

Summary for 7LM2

• Entry DOI: 10.2210/pdb7lm2/pdb
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, cyclopropyl[(3S)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}pyrrolidin-1-yl]methanone, ... (6 entities in total)
• Functional Keywords: pi3kdelta kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 138292.01

Authors

Lesburg, C.A.,Augustin, M. (deposition date: 2021-02-05, release date: 2021-04-21, Last modification date: 2024-04-03)

• Primary citation: Methot, J.L.,Zhou, H.,McGowan, M.A.,Anthony, N.J.,Christopher, M.,Garcia, Y.,Achab, A.,Lipford, K.,Trotter, B.W.,Altman, M.D.,Fradera, X.,Lesburg, C.A.,Li, C.,Alves, S.,Chappell, C.P.,Jain, R.,Mangado, R.,Pinheiro, E.,Williams, S.M.G.,Goldenblatt, P.,Hill, A.,Shaffer, L.,Chen, D.,Tong, V.,McLeod, R.L.,Lee, H.H.,Yu, H.,Shah, S.,Katz, J.D.; Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3K delta Immunomodulators.; J.Med.Chem., 64:5137-5156, 2021; PubMed: 33797901; DOI: 10.1021/acs.jmedchem.1c00237

Experimental method

X-RAY DIFFRACTION (2.79 Å)