Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7LM2

HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 3C

Functional Information from GO Data
ChainGOidnamespacecontents
A0001779biological_processnatural killer cell differentiation
A0001819biological_processpositive regulation of cytokine production
A0001938biological_processpositive regulation of endothelial cell proliferation
A0002250biological_processadaptive immune response
A0002551biological_processmast cell chemotaxis
A0002679biological_processrespiratory burst involved in defense response
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005942cellular_componentphosphatidylinositol 3-kinase complex
A0005943cellular_componentphosphatidylinositol 3-kinase complex, class IA
A0006468biological_processprotein phosphorylation
A0006629biological_processlipid metabolic process
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007165biological_processsignal transduction
A0010595biological_processpositive regulation of endothelial cell migration
A0010628biological_processpositive regulation of gene expression
A0010818biological_processT cell chemotaxis
A0016301molecular_functionkinase activity
A0016303molecular_function1-phosphatidylinositol-3-kinase activity
A0030101biological_processnatural killer cell activation
A0030154biological_processcell differentiation
A0030183biological_processB cell differentiation
A0030217biological_processT cell differentiation
A0030335biological_processpositive regulation of cell migration
A0030593biological_processneutrophil chemotaxis
A0033031biological_processpositive regulation of neutrophil apoptotic process
A0035005molecular_function1-phosphatidylinositol-4-phosphate 3-kinase activity
A0035747biological_processnatural killer cell chemotaxis
A0035754biological_processB cell chemotaxis
A0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
A0038084biological_processvascular endothelial growth factor signaling pathway
A0042110biological_processT cell activation
A0042113biological_processB cell activation
A0043303biological_processmast cell degranulation
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0045087biological_processinnate immune response
A0045766biological_processpositive regulation of angiogenesis
A0046854biological_processphosphatidylinositol phosphate biosynthetic process
A0046934molecular_function1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
A0048015biological_processphosphatidylinositol-mediated signaling
A0050852biological_processT cell receptor signaling pathway
A0050853biological_processB cell receptor signaling pathway
A0060374biological_processmast cell differentiation
A0072672biological_processneutrophil extravasation
A1905278biological_processpositive regulation of epithelial tube formation
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue Y5Y A 1101
ChainResidue
AMET752
ATRP760
ATYR813
AGLU826
AVAL828
AMET900
AILE910

site_idAC2
Number of Residues3
Detailsbinding site for residue EDO A 1102
ChainResidue
AGLU451
AVAL445
AASP447

site_idAC3
Number of Residues2
Detailsbinding site for residue SO4 A 1103
ChainResidue
ATHR811
APRO812

Functional Information from PROSITE/UniProt
site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKng.DDLRQDmltlQ
ChainResidueDetails
APHE778-GLN792

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatYVLgIgDRHsdN
ChainResidueDetails
ASER878-ASN898

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BTHR454
BGLN579

227111

PDB entries from 2024-11-06

PDB statisticsPDBj update infoContact PDBjnumon