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7LM2

HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 3C

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1APhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformpolymer1020116861.91UniProt (O00329)
Pfam (PF02192)
Pfam (PF00794)
Pfam (PF00792)
Pfam (PF00613)
Pfam (PF00454)
In PDB
Homo sapiens (Human)PtdIns-3-kinase subunit delta,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta,p110delta
2BPhosphatidylinositol 3-kinase regulatory subunit alphapolymer16920879.61UniProt (P27986)
Pfam (PF16454)
In PDB
Homo sapiens (Human)PtdIns-3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PtdIns-3-kinase regulatory subunit p85-alpha
3Acyclopropyl[(3S)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}pyrrolidin-1-yl]methanonenon-polymer392.51Chemie (Y5Y)
4A1,2-ETHANEDIOLnon-polymer62.11Chemie (EDO)
5ASULFATE IONnon-polymer96.11Chemie (SO4)
6waterwater18.08Chemie (HOH)
Sequence modifications
B: 431 - 599 (UniProt: P27986)
PDBExternal DatabaseDetails
Asp 469Glu 169conflict
Thr 519Lys 219conflict
Glu 529Asp 229conflict
Val 539Ile 239conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight137741.4
Non-Polymers*Number of molecules3
Total formula weight550.6
All*Total formula weight138292.0
*Water molecules are not included.

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