7LLF

SARS-CoV-2 papain-like protease (PLpro) bound to inhibitor XR8-83

Summary for 7LLF

• Entry DOI: 10.2210/pdb7llf/pdb
• Related: 7LBR 7LBS
• Descriptor: Non-structural protein 3, ZINC ION, SULFATE ION, ... (7 entities in total)
• Functional Keywords: papain-like protease, coronavirus inhibitor, sars-cov-2, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• Total number of polymer chains: 2
• Total formula weight: 73449.49

Authors

Ratia, K.M.,Xiong, R.,Thatcher, G.R. (deposition date: 2021-02-03, release date: 2021-02-24, Last modification date: 2023-10-18)

• Primary citation: Shen, Z.,Ratia, K.,Cooper, L.,Kong, D.,Lee, H.,Kwon, Y.,Li, Y.,Alqarni, S.,Huang, F.,Dubrovskyi, O.,Rong, L.,Thatcher, G.R.,Xiong, R.; Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures.; Biorxiv, 2021; PubMed: 33594371; DOI: 10.1101/2021.02.13.431008

Experimental method

X-RAY DIFFRACTION (2.3 Å)