7LKL

The internal aldimine form of the wild-type Salmonella typhimurium Tryptophan Synthase in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) at the enzyme alpha-site, cesium ion at the metal coordination site and the product L-tryptophan at the enzyme beta-site at 1.05 Angstrom resolution. One of the beta-Q114 rotamer conformations allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring

Summary for 7LKL

• Entry DOI: 10.2210/pdb7lkl/pdb
• Related: 5CGQ
• Descriptor: Tryptophan synthase alpha chain, PYRIDOXAL-5'-PHOSPHATE, Tryptophan synthase beta chain, ... (11 entities in total)
• Functional Keywords: inhibitor, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Salmonella enterica subsp. enterica serovar Typhimurium; More
• Total number of polymer chains: 2
• Total formula weight: 75337.53

Authors

Hilario, E.,Dunn, M.F.,Mueller, L.J. (deposition date: 2021-02-02, release date: 2022-02-02, Last modification date: 2023-10-18)

• Primary citation: Hilario, E.,Dunn, M.F.,Mueller, L.J.; The internal aldimine form of the wild-type Salmonella typhimurium Tryptophan Synthase in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) at the enzyme alpha-site, cesium ion at the metal coordination site and the product L-tryptophan at the enzyme beta-site at 1.05 Angstrom resolution. One of the beta-Q114 rotamer conformations allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring.; To be Published,

Experimental method

X-RAY DIFFRACTION (1.05 Å)