7LKL
The internal aldimine form of the wild-type Salmonella typhimurium Tryptophan Synthase in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) at the enzyme alpha-site, cesium ion at the metal coordination site and the product L-tryptophan at the enzyme beta-site at 1.05 Angstrom resolution. One of the beta-Q114 rotamer conformations allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring
Summary for 7LKL
Entry DOI | 10.2210/pdb7lkl/pdb |
Related | 5CGQ |
Descriptor | Tryptophan synthase alpha chain, PYRIDOXAL-5'-PHOSPHATE, Tryptophan synthase beta chain, ... (11 entities in total) |
Functional Keywords | inhibitor, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Salmonella enterica subsp. enterica serovar Typhimurium More |
Total number of polymer chains | 2 |
Total formula weight | 75337.53 |
Authors | Hilario, E.,Dunn, M.F.,Mueller, L.J. (deposition date: 2021-02-02, release date: 2022-02-02, Last modification date: 2023-10-18) |
Primary citation | Hilario, E.,Dunn, M.F.,Mueller, L.J. The internal aldimine form of the wild-type Salmonella typhimurium Tryptophan Synthase in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) at the enzyme alpha-site, cesium ion at the metal coordination site and the product L-tryptophan at the enzyme beta-site at 1.05 Angstrom resolution. One of the beta-Q114 rotamer conformations allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring. To be Published, |
Experimental method | X-RAY DIFFRACTION (1.05 Å) |
Structure validation
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