7LKL
The internal aldimine form of the wild-type Salmonella typhimurium Tryptophan Synthase in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) at the enzyme alpha-site, cesium ion at the metal coordination site and the product L-tryptophan at the enzyme beta-site at 1.05 Angstrom resolution. One of the beta-Q114 rotamer conformations allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tryptophan synthase alpha chain | polymer | 268 | 28698.8 | 1 | UniProt (A0A0D6FWC1) Pfam (PF00290) UniProt (by SIFTS) (P00929) In PDB | Salmonella enterica subsp. enterica serovar Typhimurium | |
| 2 | B | Tryptophan synthase beta chain | polymer | 397 | 42918.9 | 1 | UniProt (P0A2K1) Pfam (PF00291) In PDB | Salmonella enterica subsp. enterica serovar Typhimurium | |
| 3 | A | 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE | non-polymer | 365.2 | 1 | Chemie (F9F) | |||
| 4 | B, A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 13 | Chemie (DMS) | |||
| 5 | A, B | TRYPTOPHAN | non-polymer | 204.2 | 2 | Chemie (TRP) | |||
| 6 | B, A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 7 | B, A | CESIUM ION | non-polymer | 132.9 | 5 | Chemie (CS) | |||
| 8 | B, A | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 9 | B | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
| 10 | B | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 1 | Chemie (PLP) | |||
| 11 | water | water | 18.0 | 840 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71617.7 | |
| Non-Polymers* | Number of molecules | 38 |
| Total formula weight | 3719.8 | |
| All* | Total formula weight | 75337.5 |
