7LK0

Ornithine Aminotransferase (OAT) cocrystallized with its potent inhibitor - (S)-3-amino-4,4-difluorocyclopent-1-enecarboxylic acid (SS-1-148)

Summary for 7LK0

Entry DOI	10.2210/pdb7lk0/pdb
Descriptor	Ornithine aminotransferase, mitochondrial, (1R,3S)-3-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]-4-oxocyclopentane-1-carboxylic acid (3 entities in total)
Functional Keywords	ornithine aminotransferase, oat, aminotransferase, inhibitor, inactivator, ss-1-148, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	135697.76
Authors	Butrin, A.,Shen, S.,Liu, D.,Silverman, R. (deposition date: 2021-02-01, release date: 2022-02-16, Last modification date: 2023-10-18)
Primary citation	Shen, S.,Butrin, A.,Doubleday, P.F.,Melani, R.D.,Beaupre, B.A.,Tavares, M.T.,Ferreira, G.M.,Kelleher, N.L.,Moran, G.R.,Liu, D.,Silverman, R.B. Turnover and Inactivation Mechanisms for ( S )-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase. J.Am.Chem.Soc., 143:8689-8703, 2021 Cited by PubMed: 34097381 DOI: 10.1021/jacs.1c02456 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.96 Å)

Structure validation