7LEJ
Crystal structure of the second bromodomain (BD2) of human BRDT bound to Volasertib
Summary for 7LEJ
| Entry DOI | 10.2210/pdb7lej/pdb |
| Descriptor | Bromodomain testis-specific protein, N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide (3 entities in total) |
| Functional Keywords | brdt, bet, plk1, testis specific, bromodomain, gene regulation |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 14904.24 |
| Authors | Chan, A.,Karim, M.R.,Schonbrunn, E. (deposition date: 2021-01-14, release date: 2021-07-14, Last modification date: 2023-10-18) |
| Primary citation | Karim, R.M.,Bikowitz, M.J.,Chan, A.,Zhu, J.Y.,Grassie, D.,Becker, A.,Berndt, N.,Gunawan, S.,Lawrence, N.J.,Schonbrunn, E. Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J.Med.Chem., 64:15772-15786, 2021 Cited by PubMed: 34710325DOI: 10.1021/acs.jmedchem.1c01096 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
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