7LEJ
Crystal structure of the second bromodomain (BD2) of human BRDT bound to Volasertib
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Bromodomain testis-specific protein | polymer | 122 | 14285.4 | 1 | UniProt (Q58F21) Pfam (PF00439) In PDB | Homo sapiens (Human) | Cancer/testis antigen 9,CT9,RING3-like protein |
2 | A | N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide | non-polymer | 618.8 | 1 | Chemie (IBI) | |||
3 | water | water | 18.0 | 68 | Chemie (HOH) |
Sequence modifications
A: 266 - 378 (UniProt: Q58F21)
PDB | External Database | Details |
---|---|---|
Ala 257 | - | expression tag |
Ala 258 | - | expression tag |
Tyr 259 | - | expression tag |
Phe 260 | - | expression tag |
Gln 261 | - | expression tag |
Gly 262 | - | expression tag |
Ala 263 | - | expression tag |
Ala 264 | - | expression tag |
Ser 265 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 14285.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 618.8 | |
All* | Total formula weight | 14904.2 |