7LAU
Crystal structure of the first bromodomain (BD1) of human BRD2 bound to ERK5-IN-1
Summary for 7LAU
Entry DOI | 10.2210/pdb7lau/pdb |
Descriptor | Bromodomain-containing protein 2, 11-cyclopentyl-2-({2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one (3 entities in total) |
Functional Keywords | bet, erk5, dual brd-kinase inhibitor, gene regulation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15110.67 |
Authors | Karim, M.R.,Bikowitz, M.,Schonbrunn, E. (deposition date: 2021-01-06, release date: 2021-08-11, Last modification date: 2023-10-18) |
Primary citation | Karim, R.M.,Bikowitz, M.J.,Chan, A.,Zhu, J.Y.,Grassie, D.,Becker, A.,Berndt, N.,Gunawan, S.,Lawrence, N.J.,Schonbrunn, E. Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J.Med.Chem., 64:15772-15786, 2021 Cited by PubMed: 34710325DOI: 10.1021/acs.jmedchem.1c01096 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report