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7L9K

Crystal structure of the second bromodomain (BD2) of human BRD2 bound to LRRK2-IN-1

Summary for 7L9K
Entry DOI10.2210/pdb7l9k/pdb
DescriptorBromodomain-containing protein 2, 1,4-BUTANEDIOL, 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, ... (4 entities in total)
Functional Keywordsbet, erk5, dual brd-kinase inhibitor, gene regulation
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight28553.00
Authors
Karim, M.R.,Bikowitz, M.J.,Schonbrunn, E. (deposition date: 2021-01-04, release date: 2021-07-07, Last modification date: 2023-10-18)
Primary citationKarim, R.M.,Bikowitz, M.J.,Chan, A.,Zhu, J.Y.,Grassie, D.,Becker, A.,Berndt, N.,Gunawan, S.,Lawrence, N.J.,Schonbrunn, E.
Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.
J.Med.Chem., 64:15772-15786, 2021
Cited by
PubMed: 34710325
DOI: 10.1021/acs.jmedchem.1c01096
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

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