7L9K
Crystal structure of the second bromodomain (BD2) of human BRD2 bound to LRRK2-IN-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Bromodomain-containing protein 2 | polymer | 114 | 13375.4 | 2 | UniProt (P25440) Pfam (PF00439) In PDB | Homo sapiens (Human) | O27.1.1,Really interesting new gene 3 protein |
| 2 | A | 1,4-BUTANEDIOL | non-polymer | 90.1 | 1 | Chemie (BU1) | |||
| 3 | A, B | 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one | non-polymer | 570.7 | 3 | Chemie (4K4) | |||
| 4 | water | water | 18.0 | 193 | Chemie (HOH) |
Sequence modifications
A, B: 344 - 455 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Ser 342 | - | expression tag |
| Met 343 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26750.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1802.2 | |
| All* | Total formula weight | 28553.0 |
