7L72
Crystal structure of the second bromodomain (BD2) of human BRD3 bound to Ro3280
Summary for 7L72
| Entry DOI | 10.2210/pdb7l72/pdb |
| Descriptor | Bromodomain-containing protein 3, 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide (3 entities in total) |
| Functional Keywords | bet, plk1, epigenetics, gene regulation |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 13851.01 |
| Authors | Karim, M.R.,Bikowitz, M.,Schonbrunn, E. (deposition date: 2020-12-25, release date: 2021-11-17, Last modification date: 2023-10-18) |
| Primary citation | Karim, R.M.,Bikowitz, M.J.,Chan, A.,Zhu, J.Y.,Grassie, D.,Becker, A.,Berndt, N.,Gunawan, S.,Lawrence, N.J.,Schonbrunn, E. Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J.Med.Chem., 64:15772-15786, 2021 Cited by PubMed: 34710325DOI: 10.1021/acs.jmedchem.1c01096 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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