7L25
HPK1 IN COMPLEX WITH COMPOUND 18
Summary for 7L25
Entry DOI | 10.2210/pdb7l25/pdb |
Descriptor | Mitogen-activated protein kinase kinase kinase kinase 1, 6-(2-fluoro-6-methoxyphenyl)-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-1H-pyrazolo[4,3-c]pyridine, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | hpk1 hematopoietic progenitor kinase, inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 65950.85 |
Authors | Lesburg, C.A. (deposition date: 2020-12-16, release date: 2021-03-17, Last modification date: 2024-04-03) |
Primary citation | Yu, E.C.,Methot, J.L.,Fradera, X.,Lesburg, C.A.,Lacey, B.M.,Siliphaivanh, P.,Liu, P.,Smith, D.M.,Xu, Z.,Piesvaux, J.A.,Kawamura, S.,Xu, H.,Miller, J.R.,Bittinger, M.,Pasternak, A. Identification of Potent Reverse Indazole Inhibitors for HPK1. Acs Med.Chem.Lett., 12:459-466, 2021 Cited by PubMed: 33738073DOI: 10.1021/acsmedchemlett.0c00672 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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