7L1X

Structure of human CK2 alpha kinase (catalytic subunit) with the inhibitor 108600.

Summary for 7L1X

Entry DOI	10.2210/pdb7l1x/pdb
Descriptor	Casein kinase II subunit alpha, SULFATE ION, GLYCEROL, ... (5 entities in total)
Functional Keywords	inhibitor 108600, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	40950.29
Authors	Rechkoblit, O.,Aggarwal, A.K. (deposition date: 2020-12-15, release date: 2021-08-11, Last modification date: 2023-10-18)
Primary citation	Sato, K.,Padgaonkar, A.A.,Baker, S.J.,Cosenza, S.C.,Rechkoblit, O.,Subbaiah, D.R.C.V.,Domingo-Domenech, J.,Bartkowski, A.,Port, E.R.,Aggarwal, A.K.,Ramana Reddy, M.V.,Irie, H.Y.,Premkumar Reddy, E. Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease. Nat Commun, 12:4671-4671, 2021 Cited by PubMed: 34344863 DOI: 10.1038/s41467-021-24878-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation