7L1J

Mycobacterium tuberculosis dethiobiotin synthetase in complex with Tetrazole 1

Summary for 7L1J

Entry DOI	10.2210/pdb7l1j/pdb
Related	6NMZ 6NNZ 6NU6 6NVC 6NVE 6NVF 6NWG 7JT5 7JT6
Descriptor	ATP-dependent dethiobiotin synthetase BioD, {(1R,2R)-2-[4-(1H-tetrazol-5-yl)benzene-1-carbonyl]cyclopentyl}propanedioic acid, GLYCEROL, ... (5 entities in total)
Functional Keywords	inhibitor, ligase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	4
Total formula weight	95464.70
Authors	Pederick, J.L.,Bruning, J.B. (deposition date: 2020-12-14, release date: 2021-10-27, Last modification date: 2023-10-18)
Primary citation	Schumann, N.C.,Lee, K.J.,Thompson, A.P.,Salaemae, W.,Pederick, J.L.,Avery, T.,Gaiser, B.I.,Hodgkinson-Bean, J.,Booker, G.W.,Polyak, S.W.,Bruning, J.B.,Wegener, K.L.,Abell, A.D. Inhibition of Mycobacterium tuberculosis Dethiobiotin Synthase ( Mt DTBS): Toward Next-Generation Antituberculosis Agents. Acs Chem.Biol., 16:2339-2347, 2021 Cited by PubMed: 34533923 DOI: 10.1021/acschembio.1c00491 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation