7JT5
Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 9
Summary for 7JT5
Entry DOI | 10.2210/pdb7jt5/pdb |
Related | 6NLZ 6NMZ 6NNZ 6NU6 6NVC 6NVE 6NVF 6NWG |
Descriptor | ATP-dependent dethiobiotin synthetase BioD, GLYCEROL, {(1R,2R)-2-[4-(carboxymethyl)benzene-1-carbonyl]cyclopentyl}propanedioic acid, ... (5 entities in total) |
Functional Keywords | inhibitor, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 4 |
Total formula weight | 95905.01 |
Authors | Pederick, J.P.,Bruning, J.B. (deposition date: 2020-08-17, release date: 2021-09-08, Last modification date: 2023-10-18) |
Primary citation | Schumann, N.C.,Lee, K.J.,Thompson, A.P.,Salaemae, W.,Pederick, J.L.,Avery, T.,Gaiser, B.I.,Hodgkinson-Bean, J.,Booker, G.W.,Polyak, S.W.,Bruning, J.B.,Wegener, K.L.,Abell, A.D. Inhibition of Mycobacterium tuberculosis Dethiobiotin Synthase ( Mt DTBS): Toward Next-Generation Antituberculosis Agents. Acs Chem.Biol., 16:2339-2347, 2021 Cited by PubMed: 34533923DOI: 10.1021/acschembio.1c00491 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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