7JT5

Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 9

Summary for 7JT5

Entry DOI	10.2210/pdb7jt5/pdb
Related	6NLZ 6NMZ 6NNZ 6NU6 6NVC 6NVE 6NVF 6NWG
Descriptor	ATP-dependent dethiobiotin synthetase BioD, GLYCEROL, {(1R,2R)-2-[4-(carboxymethyl)benzene-1-carbonyl]cyclopentyl}propanedioic acid, ... (5 entities in total)
Functional Keywords	inhibitor, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	4
Total formula weight	95905.01
Authors	Pederick, J.P.,Bruning, J.B. (deposition date: 2020-08-17, release date: 2021-09-08, Last modification date: 2023-10-18)
Primary citation	Schumann, N.C.,Lee, K.J.,Thompson, A.P.,Salaemae, W.,Pederick, J.L.,Avery, T.,Gaiser, B.I.,Hodgkinson-Bean, J.,Booker, G.W.,Polyak, S.W.,Bruning, J.B.,Wegener, K.L.,Abell, A.D. Inhibition of Mycobacterium tuberculosis Dethiobiotin Synthase ( Mt DTBS): Toward Next-Generation Antituberculosis Agents. Acs Chem.Biol., 16:2339-2347, 2021 Cited by PubMed: 34533923 DOI: 10.1021/acschembio.1c00491 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation