7L1D

Crystal structure of human 21LT2-2 TCR bound to HLA-A*03:01 in complex with a mutant PIK3CA peptide

7L1D の概要

• エントリーDOI: 10.2210/pdb7l1d/pdb
• 分子名称: HLA class I histocompatibility antigen, A alpha chain, Beta-2-microglobulin, Mutant PIK3CA peptide, ... (7 entities in total)
• 機能のキーワード: t cell receptor, peptide major histocompatibility complex, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 95000.04

構造登録者

Ma, J.,Baker, B.M. (登録日: 2020-12-14, 公開日: 2022-03-23, 最終更新日: 2023-10-18)

• 主引用文献: Chandran, S.S.,Ma, J.,Klatt, M.G.,Dundar, F.,Bandlamudi, C.,Razavi, P.,Wen, H.Y.,Weigelt, B.,Zumbo, P.,Fu, S.N.,Banks, L.B.,Yi, F.,Vercher, E.,Etxeberria, I.,Bestman, W.D.,Da Cruz Paula, A.,Aricescu, I.S.,Drilon, A.,Betel, D.,Scheinberg, D.A.,Baker, B.M.,Klebanoff, C.A.; Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.; Nat Med, 28:946-957, 2022; PubMed: 35484264; DOI: 10.1038/s41591-022-01786-3

実験手法

X-RAY DIFFRACTION (3.11 Å)