7L0G
Monobody 12VC1 Bound to HRAS(G12C)
Summary for 7L0G
Entry DOI | 10.2210/pdb7l0g/pdb |
Descriptor | GTPase HRas, Monobody 12VC1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... (5 entities in total) |
Functional Keywords | ras gtpase, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 119205.99 |
Authors | Teng, K.W.,Hattori, T.,Tsai, S.,Koide, S. (deposition date: 2020-12-11, release date: 2021-03-24, Last modification date: 2023-10-18) |
Primary citation | Teng, K.W.,Tsai, S.T.,Hattori, T.,Fedele, C.,Koide, A.,Yang, C.,Hou, X.,Zhang, Y.,Neel, B.G.,O'Bryan, J.P.,Koide, S. Selective and noncovalent targeting of RAS mutants for inhibition and degradation. Nat Commun, 12:2656-2656, 2021 Cited by PubMed: 33976200DOI: 10.1038/s41467-021-22969-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.54 Å) |
Structure validation
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