7L0G

Monobody 12VC1 Bound to HRAS(G12C)

Summary for 7L0G

Entry DOI	10.2210/pdb7l0g/pdb
Descriptor	GTPase HRas, Monobody 12VC1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... (5 entities in total)
Functional Keywords	ras gtpase, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	8
Total formula weight	119205.99
Authors	Teng, K.W.,Hattori, T.,Tsai, S.,Koide, S. (deposition date: 2020-12-11, release date: 2021-03-24, Last modification date: 2023-10-18)
Primary citation	Teng, K.W.,Tsai, S.T.,Hattori, T.,Fedele, C.,Koide, A.,Yang, C.,Hou, X.,Zhang, Y.,Neel, B.G.,O'Bryan, J.P.,Koide, S. Selective and noncovalent targeting of RAS mutants for inhibition and degradation. Nat Commun, 12:2656-2656, 2021 Cited by PubMed: 33976200 DOI: 10.1038/s41467-021-22969-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.54 Å)

Structure validation