7L05

Complex of novel maytansinoid M24 bound to T2R-TTL (two tubulin alpha/beta heterodimers, RB3 stathmin-like domain, and tubulin tyrosine ligase)

7L05 の概要

• エントリーDOI: 10.2210/pdb7l05/pdb
• 分子名称: Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (14 entities in total)
• 機能のキーワード: maytansinoid, tubulin, antibody-drug conjugate, structural protein
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 266147.93

構造登録者

Franklin, M.C. (登録日: 2020-12-11, 公開日: 2021-12-22, 最終更新日: 2023-10-18)

• 主引用文献: DaSilva, J.O.,Yang, K.,Surriga, O.,Nittoli, T.,Kunz, A.,Franklin, M.C.,Delfino, F.J.,Mao, S.,Zhao, F.,Giurleo, J.T.,Kelly, M.P.,Makonnen, S.,Hickey, C.,Krueger, P.,Foster, R.,Chen, Z.,Retter, M.W.,Slim, R.,Young, T.M.,Olson, W.C.,Thurston, G.,Daly, C.; A Biparatopic Antibody-Drug Conjugate to Treat MET-Expressing Cancers, Including Those that Are Unresponsive to MET Pathway Blockade.; Mol.Cancer Ther., 20:1966-1976, 2021; PubMed: 34315762; DOI: 10.1158/1535-7163.MCT-21-0009

実験手法

X-RAY DIFFRACTION (2.21 Å)