7KXT
Crystal structure of human EED
Summary for 7KXT
Entry DOI | 10.2210/pdb7kxt/pdb |
Descriptor | Polycomb protein EED, 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, UNKNOWN ATOM OR ION, ... (4 entities in total) |
Functional Keywords | eed, wd40, structural genomics, structural genomics consortium, sgc, gene regulation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 93233.84 |
Authors | Zhu, L.,Dong, A.,Du, D.,Liu, Y.,Luo, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2020-12-04, release date: 2021-02-24, Last modification date: 2023-10-18) |
Primary citation | Du, D.,Xu, D.,Zhu, L.,Stazi, G.,Zwergel, C.,Liu, Y.,Luo, Z.,Li, Y.,Zhang, Y.,Zhu, K.,Ding, Y.,Liu, J.,Fan, S.,Zhao, K.,Zhang, N.,Kong, X.,Jiang, H.,Chen, K.,Zhao, K.,Valente, S.,Min, J.,Duan, W.,Luo, C. Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction. J.Med.Chem., 64:8194-8207, 2021 Cited by PubMed: 34077206DOI: 10.1021/acs.jmedchem.0c02261 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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