7KR5

Cryo-EM structure of the CRAC channel Orai in an open conformation; H206A gain-of-function mutation in complex with an antibody

Summary for 7KR5

• Entry DOI: 10.2210/pdb7kr5/pdb
• EMDB information: 23002
• Descriptor: Calcium release-activated calcium channel protein 1, 19B5 Fab heavy chain, 19B5 Fab light chain, ... (4 entities in total)
• Functional Keywords: ion channel, calcium, soce, crac, eukaryotic, open structure, membrane protein, amphiboles, cryo-em, transport protein-immune system complex, transport protein/immune system
• Biological source: Drosophila melanogaster (Fruit fly); More
• Total number of polymer chains: 12
• Total formula weight: 302422.40

Authors

Long, S.B.,Hou, X.,Outhwaite, I.R. (deposition date: 2020-11-18, release date: 2020-12-09)

• Primary citation: Hou, X.,Outhwaite, I.R.,Pedi, L.,Long, S.B.; Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation.; Elife, 9:-, 2020; PubMed: 33252040; DOI: 10.7554/eLife.62772

Experimental method

ELECTRON MICROSCOPY (3.3 Å)