7KQJ
CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C (NHIS-RORGT(244-487)-L6-SRC1(678-692) IN COMPLEX WITH A NOVEL TRICYCLIC-CARBOCYLIC RORGT INVERSE AGONIST
Summary for 7KQJ
| Entry DOI | 10.2210/pdb7kqj/pdb |
| Descriptor | Nuclear receptor ROR-gamma, N-[(3R,3aS,9bS)-9b-[(4-fluorophenyl)sulfonyl]-7-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[a]naphthalen-3-yl]-2-hydroxy-2-methylpropanamide (3 entities in total) |
| Functional Keywords | rorgt, nuclear hormone receptor, ligand-binding domain, transcription, transcription-agonist complex, transcription/agonist |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 33486.46 |
| Authors | Sack, J.S. (deposition date: 2020-11-16, release date: 2021-02-24, Last modification date: 2023-10-18) |
| Primary citation | Yang, M.G.,Beaudoin-Bertrand, M.,Xiao, Z.,Marcoux, D.,Weigelt, C.A.,Yip, S.,Wu, D.R.,Ruzanov, M.,Sack, J.S.,Wang, J.,Yarde, M.,Li, S.,Shuster, D.J.,Xie, J.H.,Sherry, T.,Obermeier, M.T.,Fura, A.,Stefanski, K.,Cornelius, G.,Khandelwal, P.,Karmakar, A.,Basha, M.,Babu, V.,Gupta, A.K.,Mathur, A.,Salter-Cid, L.,Denton, R.,Zhao, Q.,Dhar, T.G.M. Tricyclic-Carbocyclic ROR gamma t Inverse Agonists-Discovery of BMS-986313. J.Med.Chem., 64:2714-2724, 2021 Cited by PubMed Abstract: SAR efforts directed at identifying RORγt inverse agonists structurally different from our clinical compound (BMS-986251) led to tricyclic-carbocyclic analogues represented by - and culminated in the identification of (BMS-986313), with structural differences distinct from . The X-ray co-crystal structure of with the ligand binding domain of RORγt revealed several key interactions, which are different from . The in vitro and in vivo PK profiles of are described. In addition, we demonstrate robust efficacy of in two preclinical models of psoriasis-the IMQ-induced skin lesion model and the IL-23-induced acanthosis model. The efficacy seen with in these models is comparable to the results observed with . PubMed: 33591748DOI: 10.1021/acs.jmedchem.0c01992 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.645 Å) |
Structure validation
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