7KQJ
CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C (NHIS-RORGT(244-487)-L6-SRC1(678-692) IN COMPLEX WITH A NOVEL TRICYCLIC-CARBOCYLIC RORGT INVERSE AGONIST
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Nuclear receptor ROR-gamma | polymer | 285 | 32886.9 | 1 | UniProt (P51449) Pfam (PF00104) In PDB | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
2 | A | N-[(3R,3aS,9bS)-9b-[(4-fluorophenyl)sulfonyl]-7-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[a]naphthalen-3-yl]-2-hydroxy-2-methylpropanamide | non-polymer | 599.5 | 1 | Chemie (Z8G) | |||
3 | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A: 265 - 508 (UniProt: P51449)
PDB | External Database | Details |
---|---|---|
Met 244 | - | expression tag |
Gly 245 | - | expression tag |
Ser 246 | - | expression tag |
Ser 247 | - | expression tag |
His 248 | - | expression tag |
His 249 | - | expression tag |
His 250 | - | expression tag |
His 251 | - | expression tag |
His 252 | - | expression tag |
His 253 | - | expression tag |
Ser 254 | - | expression tag |
Ser 255 | - | expression tag |
Gly 256 | - | expression tag |
Leu 257 | - | expression tag |
Val 258 | - | expression tag |
Pro 259 | - | expression tag |
Arg 260 | - | expression tag |
Gly 261 | - | expression tag |
Ser 262 | - | expression tag |
His 263 | - | expression tag |
Met 264 | - | expression tag |
Ser 509 | - | expression tag |
Gly 510 | - | expression tag |
Gly 511 | - | expression tag |
Ser 512 | - | expression tag |
Gly 513 | - | expression tag |
Gly 514 | - | expression tag |
Leu 515 | - | expression tag |
Thr 516 | - | expression tag |
Glu 517 | - | expression tag |
Arg 518 | - | expression tag |
His 519 | - | expression tag |
Lys 520 | - | expression tag |
Ile 521 | - | expression tag |
Leu 522 | - | expression tag |
His 523 | - | expression tag |
Arg 524 | - | expression tag |
Leu 525 | - | expression tag |
Leu 526 | - | expression tag |
Gln 527 | - | expression tag |
Glu 528 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 32886.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 599.5 | |
All* | Total formula weight | 33486.5 |