7KPB

Human TNF-alpha TNFR1 complex bound to conformationally selective antibody

7KPB の概要

• エントリーDOI: 10.2210/pdb7kpb/pdb
• 分子名称: Tumor necrosis factor, Tumor necrosis factor receptor superfamily member 1A, Fab1974 - Light Chain, ... (8 entities in total)
• 機能のキーワード: tumour necrosis factor alpha, tnf, asymmetric, protein-protein inhibitor, cytokine, fragment antibody, fab, cytokine-immune system complex, cytokine/immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 7
• 化学式量合計: 134088.09

構造登録者

Fox III, D.,Conrady, D.G.,Lowe, M.,Ceska, T. (登録日: 2020-11-10, 公開日: 2021-01-13, 最終更新日: 2024-04-03)

• 主引用文献: Lightwood, D.J.,Munro, R.J.,Porter, J.,McMillan, D.,Carrington, B.,Turner, A.,Scott-Tucker, A.,Hickford, E.S.,Schmidt, A.,Fox III, D.,Maloney, A.,Ceska, T.,Bourne, T.,O'Connell, J.,Lawson, A.D.G.; A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF; Nat Commun, 12:583-583, 2021; PubMed: 33495445; DOI: 10.1038/s41467-020-20825-6

実験手法

X-RAY DIFFRACTION (3 Å)