7KMY

Structure of Mtb Lpd bound to 010705

7KMY の概要

• エントリーDOI: 10.2210/pdb7kmy/pdb
• 関連するPDBエントリー: 4M52
• 分子名称: Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, N~2~-methyl-N~2~-[(5-methyl-1H-indazol-7-yl)sulfonyl]-N-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)glycinamide, ... (5 entities in total)
• 機能のキーワード: flavoprotein, glycolysis, redox-active center, inhibitor, oxidoreductase/oxidoreductase inhibitor, oxidoreductase-oxidoreductase inhibitor complex
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 408303.59

構造登録者

Lima, C.D. (登録日: 2020-11-03, 公開日: 2021-01-27, 最終更新日: 2023-10-18)

• 主引用文献: Ginn, J.,Jiang, X.,Sun, S.,Michino, M.,Huggins, D.J.,Mbambo, Z.,Jansen, R.,Rhee, K.Y.,Arango, N.,Lima, C.D.,Liverton, N.,Imaeda, T.,Okamoto, R.,Kuroita, T.,Aso, K.,Stamford, A.,Foley, M.,Meinke, P.T.,Nathan, C.,Bryk, R.; Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions.; Acs Infect Dis., 7:435-444, 2021; PubMed: 33527832; DOI: 10.1021/acsinfecdis.0c00788

実験手法

X-RAY DIFFRACTION (2.21 Å)