7KLZ
Structure of SPOP MATH domain in complex with a Geminin peptide
Summary for 7KLZ
Entry DOI | 10.2210/pdb7klz/pdb |
Descriptor | Speckle-type POZ protein, Geminin peptide, PHOSPHATE ION (3 entities in total) |
Functional Keywords | spop, geminin, math domain, e3 ubiquitin ligase, dna damage response, dna replication, protein binding |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 35960.98 |
Authors | Cui, G.,Botuyan, M.V.,Mer, G. (deposition date: 2020-11-01, release date: 2021-08-18, Last modification date: 2023-10-18) |
Primary citation | Ma, J.,Shi, Q.,Cui, G.,Sheng, H.,Botuyan, M.V.,Zhou, Y.,Yan, Y.,He, Y.,Wang, L.,Wang, Y.,Mer, G.,Ye, D.,Wang, C.,Huang, H. SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition. Nat Commun, 12:5779-5779, 2021 Cited by PubMed: 34599168DOI: 10.1038/s41467-021-26049-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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