7KL3

The crystal structure of the 2009/H1N1/California PA endonuclease mutant E119D bound to RNA oligomer AG*CAUC (*uncleaveable bond, -UC disordered)

Summary for 7KL3

• Entry DOI: 10.2210/pdb7kl3/pdb
• Related: 6W7A 6WHM 6WS3
• Descriptor: Protein PA-X, RNA (5'-R(P*AP*GP*CP*A)-3'), GLYCEROL, ... (7 entities in total)
• Functional Keywords: nuclease, influenza, inhibitor resistance, rna oligomer, uncleaveable bond, viral protein, viral protein-rna complex, viral protein/rna
• Biological source: Influenza A virus; More
• Total number of polymer chains: 2
• Total formula weight: 25964.23

Authors

Cuypers, M.G.,Kumar, G.,White, S.W. (deposition date: 2020-10-28, release date: 2021-02-03, Last modification date: 2024-05-29)

• Primary citation: Kumar, G.,Cuypers, M.,Webby, R.R.,Webb, T.R.,White, S.W.; Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism.; Nucleic Acids Res., 49:1609-1618, 2021; PubMed: 33469660; DOI: 10.1093/nar/gkaa1294

Experimental method

X-RAY DIFFRACTION (1.99 Å)