7KKN

Structure of the catalytic domain of tankyrase 1 in complex with talazoparib

Summary for 7KKN

• Entry DOI: 10.2210/pdb7kkn/pdb
• Descriptor: Poly [ADP-ribose] polymerase, ZINC ION, (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one, ... (5 entities in total)
• Functional Keywords: parp1, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 99599.83

Authors

Gajiwala, K.S.,Ryan, K. (deposition date: 2020-10-27, release date: 2021-01-06, Last modification date: 2023-10-18)

• Primary citation: Ryan, K.,Bolanos, B.,Smith, M.,Palde, P.B.,Cuenca, P.D.,VanArsdale, T.L.,Niessen, S.,Zhang, L.,Behenna, D.,Ornelas, M.A.,Tran, K.T.,Kaiser, S.,Lum, L.,Stewart, A.,Gajiwala, K.S.; Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.; J.Biol.Chem., 296:100251-100251, 2021; PubMed: 33361107; DOI: 10.1074/jbc.RA120.016573

Experimental method

X-RAY DIFFRACTION (1.48 Å)