7KKN
Structure of the catalytic domain of tankyrase 1 in complex with talazoparib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Poly [ADP-ribose] polymerase | polymer | 213 | 24356.6 | 4 | UniProt (Q59FX0) Pfam (PF00644) UniProt (by SIFTS) (O95271) | Homo sapiens (Human) | PARP |
| 2 | E, H, K, M (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, I, L, N (A, B, C, D) | (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one | non-polymer | 380.4 | 4 | Chemie (2YQ) | |||
| 4 | G, J (A, B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
| 5 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 951 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1104 - 1314 (UniProt: Q59FX0)
| PDB | External Database | Details |
|---|---|---|
| Gly 1102 | - | expression tag |
| Ser 1103 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 97426.3 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2173.5 | |
| All* | Total formula weight | 99599.8 |
