7KIE

Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with covalent compound 3

Summary for 7KIE

• Entry DOI: 10.2210/pdb7kie/pdb
• Related: 7KIA
• Descriptor: Fibroblast growth factor receptor 2, N-{4-[(E)-2-{4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}ethenyl]phenyl}prop-2-enamide, CITRATE ANION, ... (5 entities in total)
• Functional Keywords: fgfr kinase domain, fgfr, fgfr2, fgfr3, kinase inhibitor, covalent inhibitor, gatekeeper mutant, rtk, signaling protein, tumor growth, cholangiocarcinoma
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 72106.76

Authors

Ke, J.,Wibowo, A.S.,Carter, J.J.,Larsen, N.A. (deposition date: 2020-10-23, release date: 2021-02-10, Last modification date: 2023-10-18)

• Primary citation: Brawn, R.A.,Cook, A.,Omoto, K.,Ke, J.,Karr, C.,Colombo, F.,Virrankoski, M.,Prajapati, S.,Reynolds, D.,Bolduc, D.M.,Nguyen, T.V.,Gee, P.,Borrelli, D.,Caleb, B.,Yao, S.,Irwin, S.,Larsen, N.A.,Selvaraj, A.,Zhao, X.,Ioannidis, S.; Discovery of Aminopyrazole Derivatives as Potent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2 and 3.; Acs Med.Chem.Lett., 12:93-98, 2021; PubMed: 33488969; DOI: 10.1021/acsmedchemlett.0c00517

Experimental method

X-RAY DIFFRACTION (2.47 Å)