7KIE
Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with covalent compound 3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Fibroblast growth factor receptor 2 | polymer | 308 | 35327.7 | 2 | UniProt (P21802) Pfam (PF07714) | Homo sapiens (Human) | FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor |
| 2 | C, F (A, B) | N-{4-[(E)-2-{4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}ethenyl]phenyl}prop-2-enamide | non-polymer | 444.5 | 2 | Chemie (WF7) | |||
| 3 | D, G (A, B) | CITRATE ANION | non-polymer | 189.1 | 2 | Chemie (FLC) | |||
| 4 | E, H (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 165 | Chemie (HOH) |
Sequence modifications
A, B: 461 - 768 (UniProt: P21802)
| PDB | External Database | Details |
|---|---|---|
| Phe 564 | Val 564 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70655.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1451.5 | |
| All* | Total formula weight | 72106.8 |
