7KHT
The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor Steroidogenic Factor-1 (SF-1)
Summary for 7KHT
Entry DOI | 10.2210/pdb7kht/pdb |
Descriptor | Steroidogenic factor 1, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha peptide, (2S)-3-{[(S)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane-1,2-diyl (9E,9'E)di-octadec-9-enoate, ... (4 entities in total) |
Functional Keywords | pi(3, 4, 5)p3 acyl chains, acyl chain length, acyl chain induced conformational change, nuclear pip2, nuclear pip3, nuclear receptor, lipid binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 30530.31 |
Authors | Blind, R.D. (deposition date: 2020-10-22, release date: 2021-05-19, Last modification date: 2023-10-18) |
Primary citation | Bryant, J.M.,Malabanan, M.M.,Vanderloop, B.H.,Nichols, C.M.,Haratipour, Z.,Poon, K.T.,Sherrod, S.D.,McLean, J.A.,Blind, R.D. The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor steroidogenic factor-1. J.Lipid Res., 62:100081-100081, 2021 Cited by PubMed: 33933440DOI: 10.1016/j.jlr.2021.100081 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.504 Å) |
Structure validation
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