7KHQ

Crystal structure of OXA-48 K73A in complex with meropenem

Summary for 7KHQ

• Entry DOI: 10.2210/pdb7khq/pdb
• Related: 7KH9
• Descriptor: Beta-lactamase, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: beta-lactamase, carbapenemase, beta-lactamase inhibitor, complex, oxacillinase, hydrolase, hydrolase-hydrolase inhibitor complex
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 57431.48

Authors

Palzkill, T.,Hu, L.,Sankaran, B.,Prasad, B.V.V. (deposition date: 2020-10-21, release date: 2021-02-10, Last modification date: 2023-10-18)

• Primary citation: Stojanoski, V.,Hu, L.,Sankaran, B.,Wang, F.,Tao, P.,Prasad, B.V.V.,Palzkill, T.; Mechanistic Basis of OXA-48-like beta-Lactamases' Hydrolysis of Carbapenems.; Acs Infect Dis., 7:445-460, 2021; PubMed: 33492952; DOI: 10.1021/acsinfecdis.0c00798

Experimental method

X-RAY DIFFRACTION (2 Å)